Figure 5.

IP-10, MCP-1, and RANTES, but not IL-8 expression is significantly reduced in psoriatic skin treated with a GS-NO ointment. Vehicle alone (A, C, E, G) or 1% GS-NO ointment (B, D, F, H) were applied on two distinct psoriasis plaques. Skin biopsies were taken after 14 days and processed for immunohistochemistry on frozen sections. Reactivity was revealed by using avidin-biotin-peroxidase complex and amino-ethylcarbazole. Sections were counterstained with Mayer’s hematoxylin. Results are representative of staining performed on biopsies from three patients. Original magnifications, ×100.