Table 2.
Down-Regulated Genes in HER2/neu-Positive Breast Cancer Cell Lines (N = 46)
| Accession number | Gene | BC | OC | Chromosome location | Average expression ratio |
|---|---|---|---|---|---|
| AA872383 | Metallothionein 1E | X | 16q13 | −3.85 | |
| N93476 | Endothelial differentiation sphingolipid G-protein-coupled receptor 1 | 1pter-qter | −3.32 | ||
| AA486321 | Vimentin | X | 10p13 | −3.31 | |
| AI022299 | High-mobility group protein 17 | 1p36.1 | −3.24 | ||
| AA634006 | Aortic-type smooth muscle α-actin gene | X | 10q22-24 | −3.11 | |
| H63077 | Annexin I | X | 9q11-22 | −2.98 | |
| AA127217 | EST | 1 | −2.78 | ||
| H79839 | EST | U/K | −2.61 | ||
| T50282 | Tissue factor pathway inhibitor (LAC1) | X | 2q13-32.1 | −2.61 | |
| AA991578 | Vitelliform macular dystrophy (bestrophin) | 11q13 | −2.55 | ||
| AI44462 | EST | U/K | −2.54 | ||
| AI017394 | EST | 12 | −2.52 | ||
| AA862465 | α2-glycoprotein 1, zinc | X | 7q22.1 | −2.48 | |
| AA427954 | EST | 12 | −2.48 | ||
| AA111865 | EST | 8 | −2.39 | ||
| R93124 | Aldo-keto reductase family 1, member C1 | X | 10p15-14 | −2.38 | |
| AA913304 | Heat shock transcription factor 2 | 6 | −2.36 | ||
| AA878089 | EST | U/K | −2.35 | ||
| AA436384 | EST | 1 | −2.31 | ||
| AI089149 | KIAA0448 | 1 | −2.28 | ||
| AA922705 | Glycogen phosphorylase isotype BB | X | 20p11.2-11.1 | −2.27 | |
| AA010360 | EST | 4 | −2.25 | ||
| AA496007 | EST | 5 | −2.20 | ||
| R97503 | EST | 3 | −2.19 | ||
| H79022 | EST | U/K | −2.19 | ||
| AA989257 | Interleukin 4 | X | 12q13 | −2.18 | |
| T71284 | Complement 1q | 1p36.1 | −2.18 | ||
| AI347695 | Mitochondrial translational release factor 1 | 13q14.1-14.3 | −2.17 | ||
| AA456063 | EST | 12 | −2.16 | ||
| AA448261 | High-mobility group protein isoforms I & Y | X | 6p21 | −2.06 | |
| AA865147 | EST | 4 | −2.06 | ||
| AI357378 | Macrophage lectin 2 | U/K | −2.04 | ||
| R48312 | EST | 1 | −2.03 | ||
| R83355 | EST | 6 | −2.00 | ||
| AA459364 | EST | 8 | −2.00 | ||
| AA259151 | EST | U/K | −1.99 | ||
| AA634028 | SB class II histocompatibility antigen α-chain | 6p21.3 | −1.98 | ||
| AI000935 | EST | 11 | −1.98 | ||
| AA862717 | Cas-Br-M (murine) ectropic retroviral transforming sequence B | 3q | −1.97 | ||
| H15570 | EST | U/K | −1.96 | ||
| AA677200 | EST | 11 | −1.95 | ||
| AA97960 | EST | 20 | −1.91 | ||
| AA961361 | Transforming acidic coiled coil containing protein 1 (TACC1) | X | 8p11 | −1.90 | |
| H50623 | MHC class II HLA-DR7-β-chain | 6p21.3 | −1.88 | ||
| AA931758 | G0S2 protein | 1q32.2-41 | −1.87 | ||
| N34316 | EST | 17 | −1.84 | ||
| AI264651 | mRNA sequence from H.sapiens clone 24649 | 19 | −1.83 |
BC, breast cancer-associated gene; OC, other cancer-associated gene; U/K, unknown.