Figure 6.

MLPA results for 21 probes on 9p21 for 5 TCC samples. a: Tumor with no copy number change in region. b: Tumor with minimal normal DNA contamination showing clear homozygous deletion with no products for probes encompassing p15, p14^ARF, and p16. c: Tumor with homozygous deletion of all three genes but distinct centromeric breakpoint. d: Tumor with homozygous deletion encompassing p14^ARF and p16 but not p15. e: Tumor scored as having homozygous deletion of p16 exon 2 alone by RTQ-PCR using PFKL as control. MLPA result indicates under-representation rather than homozygous deletion but confirms small region of deletion involving p16 only.