Table 1.
Immune Response and Angiogenesis Genes Overexpressed in Clear Cell Renal Cell Carcinoma
| Symbol | UniGene | GenBank | Name |
|---|---|---|---|
| Gene ontology: immune response (GO:0006955; P = 1.0 × 10−56) | |||
| AOAH | Hs.82542 | NM_001637 | Acyloxyacyl hydrolase precursor |
| APOL3 | Hs.241535 | NM_014349 | Apolipoprotein L3 isoform 2 |
| ARHGDIB | Hs.83656 | NM_001175 | Rho GDP dissociation inhibitor (GDI) β |
| BST2 | Hs.118110 | NM_004335 | Bone marrow stromal cell antigen 2 |
| C1QA | Hs.9641 | NM_015991 | Complement component 1, q, α |
| C1QB | Hs.8986 | NM_000491 | Complement component 1, q, β |
| C1QR1 | Hs.97199 | NM_012072 | Complement component 1, q, receptor 1 |
| C1R | Hs.1279 | AL573058 | Complement component 1, r |
| C1S | Hs.434029 | M18767 | Complement component 1, s |
| C3 | Hs.284394 | NM_000064 | Complement component 3 precursor |
| CCL19 | Hs.50002 | U88321 | Small inducible cytokine A19 precursor |
| CCL2 | Hs.303649 | S69738 | Small inducible cytokine A2 precursor |
| CCL20 | Hs.75498 | NM_004591 | Chemokine (C-C motif) ligand 20 |
| CCL4 | Hs.75703 | NM_002984 | Chemokine (C-C motif) ligand 4 precursor |
| CCR1 | Hs.301921 | AI421071 | Chemokine (C-C motif) receptor 1 |
| CCR2 | Hs.395 | NM_000647 | Chemokine (C-C motif) receptor 2 isoform A |
| CCR5 | Hs.54443 | NM_000579 | Chemokine (C-C motif) receptor 5 |
| CCR7 | Hs.1652 | NM_001838 | Chemokine (C-C motif) receptor 7 precursor |
| CD163 | Hs.74076 | NM_004244 | CD163 antigen |
| CD2 | Hs.89476 | NM_001767 | CD2 antigen (p50), sheep red blood cell receptor |
| CD3D | Hs.95327 | NM_000732 | CD3D antigen, δ polypeptide (TiT3 complex) |
| CD53 | Hs.82212 | NM_000560 | CD53 antigen |
| CD74 | Hs.84298 | K01144 | Invariant γ chain |
| CD8A | Hs.85258 | AW006735 | CD8 antigen alpha polypeptide isoform 1 precursor |
| CSF1R | Hs.174142 | NM_005211 | Colony-stimulating factor 1 receptor precursor |
| CSF2RB | Hs.285401 | AV756141 | Colony-stimulating factor 2 receptor, β, low-affinity |
| CST7 | Hs.143212 | AF031824 | Cystatin F |
| CXCL10 | Hs.2248 | NM_001565 | Small inducible cytokine B10 precursor |
| CXCL12 | Hs.237356 | NM_000609 | Chemokine (C-X-C motif) ligand 12 |
| CXCL14 | Hs.24395 | NM_004887 | Small inducible cytokine B14 precursor |
| CXCL9 | Hs.77367 | NM_002416 | Small inducible cytokine B9 precursor |
| ENTPD1 | Hs.205353 | AV717590 | Ectonucleoside triphosphate diphosphohydrolase 1 |
| F8 | Hs.79345 | NM_000132 | Coagulation factor VIII isoform a precursor |
| FCER1G | Hs.433300 | NM_004106 | Fc fragment of IgE, high affinity I, receptor for, γ |
| FCGR2A | Hs.78864 | NM_021642 | Fc fragment of IgG, low affinity IIa, receptor for (CD32) |
| FCGR3A | Hs.176663 | J04162 | Fc fragment of IgG, low affinity IIIa, receptor for (CD16) |
| FOS | Hs.25647 | BC004490 | c-fos |
| FPR1 | Hs.753 | NM_002029 | Formyl peptide receptor 1 |
| G1P2 | Hs.432233 | NM_005101 | Interferon, α-inducible protein (clone IFI-15K) |
| GZMA | Hs.90708 | NM_006144 | Granzyme A precursor |
| HF1 | Hs.250651 | X04697 | H factor 1 (complement) |
| HLA-DMB | Hs.1162 | NM_002118 | Major histocompatibility complex, class II, DM β |
| HLA-DPB1 | Hs.814 | NM_002121 | Major histocompatibility complex, class II, DP β 1 |
| HLA-DQA1 | Hs.198253 | BG397856 | Major histocompatibility complex, class II, DQ α 1 |
| ICSBP1 | Hs.14453 | AI073984 | Interferon consensus sequence-binding protein 1 |
| IFITM1 | Hs.458414 | MGC27165 | Interferon-induced transmembrane protein 1 (9–27) |
| IGJ | Hs.76325 | AV733266 | Immunoglobulin J polypeptide |
| IGSF6 | Hs.135194 | NM_005849 | Immunoglobulin superfamily, member 6 |
| IL10RB | Hs.173936 | BC001903 | Interleukin 10 receptor, β precursor |
| IL1R2 | Hs.25333 | NM_004633 | Interleukin 1 receptor, type II precursor |
| IL2RB | Hs.75596 | NM_000878 | Interleukin 2 receptor β precursor |
| IL2RG | Hs.84 | NM_000206 | Interleukin 2 receptor, γ chain, precursor |
| IL6 | Hs.93913 | NM_000600 | Interleukin 6 (interferon, β 2) |
| IL7R | Hs.362807 | NM_002185 | Interleukin 7 receptor precursor |
| INHBB | Hs.1735 | NM_002193 | Inhibin β B subunit precursor |
| IRF1 | Hs.80645 | NM_002198 | Interferon regulatory factor 1 |
| IRF7 | Hs.166120 | NM_004030 | Interferon regulatory factor 7 isoform a |
| ITGB2 | Hs.83968 | NM_000211 | Integrin β chain, β 2 precursor |
| ITK | Hs.211576 | D13720 | IL2-inducible T-cell kinase |
| JAG2 | Hs.166154 | AF029778 | Jagged 2 isoform a precursor |
| LCP2 | Hs.2488 | AI123251 | Lymphocyte cytosolic protein 2 |
| LIF | Hs.2250 | NM_002309 | Leukemia inhibitory factor |
| LTB | Hs.890 | NM_002341 | Lymphotoxin-β isoform a |
| MNDA | Hs.153837 | NM_002432 | Myeloid cell nuclear differentiation antigen |
| MX1 | Hs.76391 | NM_002462 | Myxovirus resistance protein 1 |
| MX2 | Hs.926 | NM_002463 | Myxovirus resistance protein 2 |
| NK4 | Hs.943 | NM_004221 | Natural killer cell transcript 4 |
| PSMB10 | Hs.9661 | NM_002801 | Proteasome β 10 subunit proprotein |
| PSMB9 | Hs.381081 | NM_002800 | Proteasome β 9 subunit isoform 1 proprotein |
| TCIRG1 | Hs.46465 | NM_006019 | T cell, immune regulator 1, isoform a |
| TLR2 | Hs.63668 | NM_003264 | Toll-like receptor 2 |
| TLR3 | Hs.29499 | NM_003265 | Toll-like receptor 3 |
| TLR7 | Hs.179152 | NM_016562 | Toll-like receptor 7 |
| TNFSF7 | Hs.99899 | NM_001252 | Tumor necrosis factor ligand superfamily, member 7 |
| TYROBP | Hs.9963 | NM_003332 | TYRO protein tyrosine kinase binding protein |
| UBD | Hs.44532 | NM_006398 | Diubiquitin |
| Gene ontology: angiogenesis (GO:0001525; P = 8.5 × 10−3) | |||
| ANGPT2 | Hs.115181 | AF187858 | Angiopoietin 2 |
| ANGPTL4 | Hs.9613 | NM_016109 | Angiopoietin-like 4 protein |
| FLT1 | Hs.381093 | AA058828 | Vascular endothelial growth factor receptor 1 |
| KDR | Hs.12337 | NM_002253 | Vascular endothelial growth factor receptor 2 |
| VEGF | Hs.73793 | AF022375 | Vascular endothelial growth factor |
| VEGFC | Hs.79141 | U58111 | Vascular endothelial growth factor C |
The significance analysis of microarrays (SAM) identified genes overexpressed in clear cell RCC versus all other tumors. The GOstat program identified gene ontology functional annotation terms that were statistically overrepresented in the clear cell RCC expression profile.