Table 4.
Muscle Development, Lipid Biosynthesis, and Pigmentation Genes Overexpressed in Angiomyolipoma
| Symbol | UniGene | GenBank | Name |
|---|---|---|---|
| Gene ontology: muscle development (GO:00075177; P = 3.6 × 10−4) | |||
| ACTA1 | Hs.1288 | NM_001100 | α1 actin precursor |
| ACTA2 | Hs.195851 | NM_001613 | α2 actin |
| ACTG2 | Hs.378774 | NM_001615 | Actin, γ2 propeptide |
| AEBP1 | Hs.439463 | NM_001129 | Adipocyte enhancer binding protein 1 precursor |
| APEG1 | Hs.21639 | NM_005876 | Aortic preferentially expressed gene 1 |
| CALD1 | Hs.325474 | AL577531 | Caldesmon 1 isoform 3 |
| COL6A3 | Hs.80988 | NM_004369 | α3 type VI collagen isoform 1 precursor |
| DMD | Hs.169470 | NM_004010 | Dystrophin Dp427c isoform |
| GATA6 | Hs.50924 | D87811 | GATA binding protein 6 |
| HDAC9 | Hs.116753 | NM_014707 | Histone deacetylase 9 isoform 3 |
| ITGB1BP2 | Hs.109999 | NM_012278 | Melusin |
| LAMA2 | Hs.75279 | NM_000426 | Laminin α2 subunit precursor |
| MYH11 | Hs.78344 | AI889739 | Smooth muscle myosin heavy chain 11 isoform SM1 |
| MYL9 | Hs.9615 | NM_006097 | Myosin regulatory light polypeptide 9 isoform a |
| TAGLN | Hs.433399 | NM_003186 | Transgelin |
| TPM1 | Hs.77899 | Z24727 | Tropomyosin 1 α |
| TPM2 | Hs.300772 | NM_003289 | Tropomyosin 2 β |
| TPM4 | Hs.250641 | AI214061 | Tropomyosin 4 |
| Gene ontology: lipid biosynthesis (GO:0008610; P = 4.5 × 10−3) | |||
| ACACA | Hs.7232 | BE855983 | Acetyl-coenzyme A carboxylase α |
| CYP51A1 | Hs.226213 | NM_000786 | Cytochrome P450, family 51 |
| FADS1 | Hs.132898 | AL512760 | Fatty acid desaturase 1 |
| FADS2 | Hs.184641 | NM_004265 | Fatty acid desaturase 2 |
| FDFT1 | Hs.48876 | BC003573 | Farnesyl-diphosphate farnesyltransferase 1 |
| ISYNA1 | Hs.405873 | AL137749 | Myo-inositol 1-phosphate synthase A1 |
| LSS | Hs.93199 | AW084510 | Lanosterol synthase |
| SR-BP1 | Hs.24447 | NM_005866 | Type I σ receptor isoform 1 |
| PBX1 | Hs.155691 | NM_002585 | Pre-B-cell leukemia transcription factor 1 |
| PC | Hs.89890 | NM_022172 | Pyruvate carboxylase precursor |
| PTGDS | Hs.430637 | NM_000954 | Prostaglandin D2 synthase 21 kd (brain) |
| RODH | Hs.11958 | U89281 | 3-Hydroxysteroid epimerase |
| SC4MOL | Hs.239926 | AV704962 | Sterol-C4-methyl oxidase-like |
| SC5DL | Hs.288031 | D85181 | Sterol-C5-desaturase-like |
| SCD | Hs.119597 | AB032261 | Stearoyl-CoA desaturase (δ-9-desaturase) |
| SIAT8A | Hs.82527 | L32867 | Sialyltransferase 8A |
| Gene ontology: pigmentation (GO:0048066; P > 0.05) | |||
| OA1 | Hs.74124 | NM_000273 | Ocular albinism 1 (Nettleship-Falls) protein |
| SILV | Hs.95972 | U01874 | Silver homolog |
| TYRP1 | Hs.75219 | NM_000550 | Tyrosinase-related protein 1 |
| UROD | Hs.78601 | M14016 | Uroporphyrinogen decarboxylase |
The significance analysis of microarrays (SAM) identified genes overexpressed in angiomyolipoma versus all other tumors. The GOstat program identified gene ontology functional annotation terms that were statistically overrepresented in the angiomyolipoma expression profile.