Table 4.
Transcriptional Sequences Differentially Expressed in the Direct Comparison of CD Versus UC PBMC Profiles
| Accession | Name | Specific to: | Fold difference | Analysis of covariance P value |
|---|---|---|---|---|
| Hs.90061 | Progesterone receptor membrane component 1 | Crohn’s | 2.08 | 2.55E-07 |
| Hs.279843 | mutL homolog 3 (E. coli) | Crohn’s | 2.00 | 2.75E-08 |
| Hs.88474 | Prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase) | Crohn’s | 1.93 | 1.18E-05 |
| Hs.73769 | Folate receptor 1 (adult) | Crohn’s | 1.93 | 6.82E-11 |
| Hs.89714 | Chemokine (C-X-C motif) ligand 5 | Crohn’s | 1.85 | 3.71E-05 |
| Hs.83381 | Guanine nucleotide binding protein (G protein), γ 11 | Crohn’s | 1.79 | 8.04E-06 |
| Hs.2359 | Dual specificity phosphatase 4 | Crohn’s | 1.76 | 5.30E-05 |
| Hs.204238 | Lipocalin 2 (oncogene 24p3) | Crohn’s | 1.75 | 4.35E-05 |
| Hs.81564 | Platelet factor 4 (chemokine (C-X-C motif) ligand 4) | Crohn’s | 1.74 | 4.38E-06 |
| Hs.119257 | ems1 sequence (mammary tumor and squamous cell Carcinoma-associated (p80/85 src substrate) | Crohn’s | 1.70 | 8.21E-05 |
| Hs.26530 | Serum deprivation response (phosphatidylserine binding protein) | Crohn’s | 1.66 | 5.34E-07 |
| Hs.303023 | Tubulin, β 1 | Crohn’s | 1.65 | 8.39E-05 |
| Hs.23581 | Leptin receptor gene-related protein | Crohn’s | 1.61 | 7.52E-05 |
| Hs.249216 | H2B histone family, member J | Crohn’s | 1.61 | 6.91E-05 |
| Hs.77439 | Protein kinase, cAMP-dependent, regulatory, type II, β | Crohn’s | 1.59 | 4.09E-05 |
| Hs.2178 | H2B histone family, member Q | Crohn’s | 1.57 | 8.85E-06 |
| Hs.114231 | C-type lectin-like receptor-2 | Crohn’s | 1.57 | 8.79E-07 |
| Hs.12813 | DKFZP434J214 protein | Crohn’s | 1.52 | 1.21E-05 |
| Hs.2164 | Pro-platelet basic protein (chemokine (C-X-C motif) ligand 7) | Crohn’s | 1.51 | 2.90E-05 |
| Hs.300697 | Immunoglobulin heavy constant γ 3 (G3m marker) | UC | 3.87 | 9.28E-13 |
| Hs.153261 | Immunoglobulin heavy constant μ | UC | 2.60 | 2.72E-05 |
| n/a | Unknown EST with consensus to immunoglobulin κ orphon | UC | 2.42 | 5.66E-05 |
| Hs.406565 | Immunoglobulin κ constant | UC | 2.30 | 1.78E-06 |
| n/a | 28 S ribosomal RNA 5′ region | UC | 2.11 | 2.95E-07 |
| Hs.406565 | Immunoglobulin κ constant | UC | 2.08 | 2.88E-08 |
| Hs.406565 | Immunoglobulin κ constant | UC | 2.04 | 3.52E-07 |
| Hs.183125 | Killer cell lectin-like receptor subfamily F, member 1 | UC | 2.02 | 5.45E-05 |
| Hs.411106 | perforin 1 | UC | 1.98 | 7.07E-05 |
| Hs.153261 | Immunoglobulin heavy constant μ | UC | 1.93 | 3.78E-05 |
| Hs.406565 | Immunoglobulin κ constant | UC | 1.88 | 2.19E-06 |
| Hs.406565 | Immunoglobulin κ constant | UC | 1.87 | 8.32E-09 |
| Hs.102950 | Coatomer protein complex, subunit γ, immunoglobulin λ joining 3 | UC | 1.74 | 5.47E-05 |
| Hs.102950 | Coatomer protein complex, subunit γ, immunoglobulin λ joining 3 | UC | 1.74 | 2.10E-05 |
| Hs.406565 | Immunoglobulin κ constant | UC | 1.72 | 2.57E-07 |
| Hs.355888 | Phospholipase C, β 2 | UC | 1.72 | 2.24E-05 |
| Hs.8272 | Prostaglandin D2 synthase 21-kd (brain) | UC | 1.71 | 5.41E-05 |
| Hs.25338 | Protease, serine, 23 | UC | 1.68 | 7.72E-05 |
| Hs.381417 | Unknown EST with consensus to immunoglobulin κ light chain variable region | UC | 1.67 | 3.86E-05 |
| Hs.75596 | Interleukin 2 receptor, β | UC | 1.65 | 7.19E-05 |
| Hs.406565 | Immunoglobulin κ constant | UC | 1.64 | 2.48E-06 |
| Hs.102950 | Coatomer protein complex, subunit γ, Immunoglobulin λ joining 3 | UC | 1.64 | 4.13E-05 |
| Hs.406565 | Immunoglobulin κ constant | UC | 1.63 | 4.95E-06 |
| Hs.406565 | Immunoglobulin κ constant | UC | 1.61 | 3.75E-08 |
| Hs.380156 | NK-receptor, killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 3 | UC | 1.60 | 3.16E-08 |
| Hs.405944 | Immunoglobulin λ locus | UC | 1.59 | 1.55E-05 |
| Hs.348935 | Immunoglobulin λ-like polypeptide 1 | UC | 1.58 | 4.69E-05 |
| Hs.84 | Interleukin 2 receptor, γ (severe combined immunodeficiency) | UC | 1.53 | 7.84E-05 |
| Hs.193128 | Homolog of C. elegans smu-1 | UC | 1.52 | 5.16E-05 |
| Hs.238944 | Hypothetical protein FLJ10631 | UC | 1.52 | 3.72E-05 |