Table 3.
Gene Marker Candidates Tested and Testing Summary
| Tissue type | Name | Identification method
|
Marker selection filters
|
||||
|---|---|---|---|---|---|---|---|
| Gene expression database query | Literature | Low expression in corresponding metastatic tissue | Marker redundancy | Tissue cross-reactivity | Marker adequate? | ||
| Lung | SP-B | x | x | x | |||
| TTF1 | x | x | x | ||||
| DSG3 | x | x | |||||
| Pancreas | PSCA | x | x | ||||
| F5 | x | x | |||||
| ITGB6 | x | x | |||||
| TGM2 | x | x | |||||
| MUC4 | x | x | x | ||||
| SERPINA 1 | x | x | |||||
| KRT7 | x | x | x | ||||
| MMP11 | x | x | |||||
| Colon | HPT1 | x | x | x | |||
| FABP1 | x | x | |||||
| CDX1 | x | x | x | ||||
| GUCY2C | x | x | x | ||||
| Prostate | PSA | x | x | x | |||
| hKLK2 | x | x | x | ||||
| Breast | MGB1 | x | x | x | |||
| PIP | x | x | x | ||||
| PDEF | x | x | |||||
| Ovarian | HE4 | x | x | x | |||
| PAX8 | x | x | x | ||||
| WT1 | x | x | x | ||||
KRT7, cytokeratin 7; MMP11, matrix metalloprotease 11; MUC4, mucin 4; PDEF, prostate-derived Ets transcription factor; SERPINA 1, serine proteinase inhibitor, clade A member 1.