Table 6.
Summary of Results for Cases with Associated B-Cell Proliferations
| Diagnosis and type of B-cell proliferation | TCRγ clonality | IGH clonality | No. EBV-labeled cells/mpf | Lineage of EBV-labeled cells |
|---|---|---|---|---|
| AILT | ||||
| Large* | + | + | ND | NA |
| Large | + | − | ND | NA |
| Large | + | − | ND | NA |
| Small | + | + | 1 to 10 | Unclear |
| Small | − | + | >100 | Subset of B cells |
| Plasma cells | + | + | Negative | NA |
| Large | + | + | Negative | NA |
| Large* | + | − | Negative | NA |
| Large | − | − | 1 to 10 | Unclear |
| Large | + | − | >100 | Subset of B cells |
| Small | + | − | 1 to 10 | Unclear |
| Small* | − | + | ND | NA |
| PTCL-NOS | ||||
| Small | + | + | Negative | NA |
| Large | + | + | 1 to 10 | Unclear |
| Large | + | + | >10 to 100 | Large B cells |
| Large | + | + | ND | NA |
| Small* | + | + | ND | NA |
| Large | + | − | 1 to 10 | Large B cells |
| Small | + | − | Negative | NA |
| Small and Large | − | − | >10 to 100 | Large B cells |
| Large* | − | − | ND | NA |
| Large | − | − | >100 | Large B cells |
| Large | + | − | >10 to 100 | Subset of B cells |
ND, not done; NA, not applicable; mpf, medium-power field
*
These B-cell proliferations met criteria for B-cell lymphoma.
The lineage of EBV-labeled cells was determined by comparison of the in situ stain to that of B- and T-cell lineage markers. In some cases, the lineage of EBV-labeled cells could not be reliably determined, and the lineage is indicated as unclear.