Table 2.
Clinicopathologic Data and Types of 41 KIT Mutation Positive, PDGFRα Mutation Negative GISTs
| No. | Sex | Age | Location | φ (cm) | Category | MC | Histomorphology | AA sequence in KIT |
|---|---|---|---|---|---|---|---|---|
| 1 | f | 69 | stomach | 1.1 | benign | 0 | spindle cell type | W557G |
| 2 | m | 79 | stomach | 0.6 | benign | 0 | spindle cell type | V559D |
| 3 | m | 68 | stomach | 4.0 | benign | 0 | spindle cell type | V556H, Q557_V560del |
| 4 | f | 52 | stomach | 4.0 | benign | 1 | spindle cell type | Y570_P576del |
| 5 | m | 66 | stomach | 3.5 | benign | 0 | spindle cell type | V555_Q556del |
| 6 | f | 61 | stomach | 3.3 | benign | 1 | spindle cell type | W557del |
| 7 | f | 69 | stomach | 0.7 | benign | 0 | spindle cell type | V560del |
| 8 | f | 75 | stomach | 1.6 | benign | 0 | spindle cell type | Q557H, W558T, K559del, I563M, N564I |
| 9 | f | 77 | stomach | 4.5 | benign | 0 | spindle cell type | S590_G602ins |
| 10 | f | 59 | stomach | 5.0 | benign | 3 | spindle cell type | V559D |
| 11 | m | 60 | stomach | 1.0 | benign | 0 | spindle cell type | A504_Y505ins* |
| 12 | m | 68 | small bowel | 1.0 | benign | 0 | mixed cell type | A504_Y505ins* |
| 13 | m | 71 | small bowel | 0.7 | benign | 0 | spindle cell type | A504_Y505ins* |
| 14 | m | 86 | stomach | 8.0 | uncertain | 0 | spindle cell type | L576P |
| 15 | f | 83 | stomach | 7.0 | uncertain | 1 | spindle cell type | V559D |
| 16 | f | 38 | small bowel | 4.5 | uncertain | 0 | mixed cell type | E561P,E562_D579del |
| 17 | f | 68 | stomach | 10.0 | uncertain | 1 | spindle cell type | D579del |
| 18 | m | 55 | small bowel | 3.0 | uncertain | 2 | spindle cell type | A504_Y505ins* |
| 19 | f | 86 | stomach | 7.0 | uncertain | 0 | spindle cell type | A504_Y505ins* |
| 20 | f | 52 | small bowel | 5.0 | uncertain | 0 | spindle cell type | A504_Y505ins* |
| 21 | m | 56 | rectum | 3.0 | uncertain | 0 | spindle cell type | A504_Y505ins* |
| 22 | m | 64 | small bowel | 9.5 | malignant | 10 | epithelioid cell type | A504_Y505ins* |
| 23 | f | 63 | stomach | 12.0 | malignant | 26 | spindle cell type | W557_K558del |
| 24 | f | 71 | stomach | 15.0 | malignant | 5 | spindle cell type | Q577_L578ins |
| 25 | f | 65 | stomach | 11.0 | malignant | 0 | spindle cell type | Q556H,W557T,K558_V559del |
| 26 | f | 35 | stomach | 7.7 | malignant | 48 | spindle cell type | W557_K558del |
| 27 | f | 46 | stomach | 9.5 | malignant | 22 | spindle cell type | W557_K558del |
| 28 | m | 50 | small bowel | 13.0 | malignant | 1 | mixed cell type | V559A |
| 29 | f | 49 | colon | 15.0 | malignant | 2 | spindle cell type | W557_K558del |
| 30 | m | 65 | stomach | 10.5 | malignant | 1 | spindle cell type | Y553N |
| 31 | f | 68 | stomach | 1.9 | malignant | 6 | spindle cell type | V559D |
| 32 | m | 42 | stomach | 29.0 | malignant | 40 | spindle cell type | W557_K558del |
| 33 | f | 74 | liver | ND | malignant | 18 | spindle cell type | A504_Y505ins* |
| 34 | m | 60 | small bowel | 6.0 | malignant | 8 | spindle cell type | V559_G565del |
| 35 | m | 57 | upper abd. | 14.0 | malignant | 16 | spindle cell type | W557_K558del |
| 36 | f | 75 | stomach | ND | malignant | 28 | epithelioid cell type | P577_L580 ins |
| 37 | f | 67 | small bowel | ND | malignant | 1 | spindle cell type | V560del |
| 38 | m | 53 | small bowel | 20.0 | malignant | 14 | spindle cell type | A504_Y505ins* |
| 39 | f | 39 | peritoneum | ND | malignant | 4 | spindle cell type | A504_Y505ins* |
| 40 | f | 68 | small bowel | 13.0 | malignant | 12 | spindle cell type | A504_Y505ins* |
| 41 | f | 34 | small bowel | 10.0 | malignant | 2 | mixed cell type | A504_Y505ins* |
Abbreviations: m, male; f, female; φ, maximum diameter in cm; MIB-1 index, percentage of cells showing nuclear staining for MIB-1; MC, mitotic count (mitoses/50 HPFs); histomorphology, histomorphological subtype according to Fletcher et al.,13; AA, amino acid; abd., abdomen; del, deletion; ins, insertion; ND, no data available;
*
, in exon 9, all others in exon 11.