Skip to main content
. 2004 Aug;6(3):197–204. doi: 10.1016/s1525-1578(10)60510-7

Table 2.

Clinicopathologic Data and Types of 41 KIT Mutation Positive, PDGFRα Mutation Negative GISTs

No. Sex Age Location φ (cm) Category MC Histomorphology AA sequence in KIT
1 f 69 stomach 1.1 benign 0 spindle cell type W557G
2 m 79 stomach 0.6 benign 0 spindle cell type V559D
3 m 68 stomach 4.0 benign 0 spindle cell type V556H, Q557_V560del
4 f 52 stomach 4.0 benign 1 spindle cell type Y570_P576del
5 m 66 stomach 3.5 benign 0 spindle cell type V555_Q556del
6 f 61 stomach 3.3 benign 1 spindle cell type W557del
7 f 69 stomach 0.7 benign 0 spindle cell type V560del
8 f 75 stomach 1.6 benign 0 spindle cell type Q557H, W558T, K559del, I563M, N564I
9 f 77 stomach 4.5 benign 0 spindle cell type S590_G602ins
10 f 59 stomach 5.0 benign 3 spindle cell type V559D
11 m 60 stomach 1.0 benign 0 spindle cell type A504_Y505ins*
12 m 68 small bowel 1.0 benign 0 mixed cell type A504_Y505ins*
13 m 71 small bowel 0.7 benign 0 spindle cell type A504_Y505ins*
14 m 86 stomach 8.0 uncertain 0 spindle cell type L576P
15 f 83 stomach 7.0 uncertain 1 spindle cell type V559D
16 f 38 small bowel 4.5 uncertain 0 mixed cell type E561P,E562_D579del
17 f 68 stomach 10.0 uncertain 1 spindle cell type D579del
18 m 55 small bowel 3.0 uncertain 2 spindle cell type A504_Y505ins*
19 f 86 stomach 7.0 uncertain 0 spindle cell type A504_Y505ins*
20 f 52 small bowel 5.0 uncertain 0 spindle cell type A504_Y505ins*
21 m 56 rectum 3.0 uncertain 0 spindle cell type A504_Y505ins*
22 m 64 small bowel 9.5 malignant 10 epithelioid cell type A504_Y505ins*
23 f 63 stomach 12.0 malignant 26 spindle cell type W557_K558del
24 f 71 stomach 15.0 malignant 5 spindle cell type Q577_L578ins
25 f 65 stomach 11.0 malignant 0 spindle cell type Q556H,W557T,K558_V559del
26 f 35 stomach 7.7 malignant 48 spindle cell type W557_K558del
27 f 46 stomach 9.5 malignant 22 spindle cell type W557_K558del
28 m 50 small bowel 13.0 malignant 1 mixed cell type V559A
29 f 49 colon 15.0 malignant 2 spindle cell type W557_K558del
30 m 65 stomach 10.5 malignant 1 spindle cell type Y553N
31 f 68 stomach 1.9 malignant 6 spindle cell type V559D
32 m 42 stomach 29.0 malignant 40 spindle cell type W557_K558del
33 f 74 liver ND malignant 18 spindle cell type A504_Y505ins*
34 m 60 small bowel 6.0 malignant 8 spindle cell type V559_G565del
35 m 57 upper abd. 14.0 malignant 16 spindle cell type W557_K558del
36 f 75 stomach ND malignant 28 epithelioid cell type P577_L580 ins
37 f 67 small bowel ND malignant 1 spindle cell type V560del
38 m 53 small bowel 20.0 malignant 14 spindle cell type A504_Y505ins*
39 f 39 peritoneum ND malignant 4 spindle cell type A504_Y505ins*
40 f 68 small bowel 13.0 malignant 12 spindle cell type A504_Y505ins*
41 f 34 small bowel 10.0 malignant 2 mixed cell type A504_Y505ins*

Abbreviations: m, male; f, female; φ, maximum diameter in cm; MIB-1 index, percentage of cells showing nuclear staining for MIB-1; MC, mitotic count (mitoses/50 HPFs); histomorphology, histomorphological subtype according to Fletcher et al.,13; AA, amino acid; abd., abdomen; del, deletion; ins, insertion; ND, no data available; 

*

, in exon 9, all others in exon 11.