Table 4.
Clinicopathologic Data and Types of 26 KIT and PDGFRα Mutation Negative GISTs
| No. | Sex | Age | Location | φ (cm) | Category | MC | Histomorphology | DNA sequence* |
|---|---|---|---|---|---|---|---|---|
| 62 | f | 83 | esophagus | 0.1 | benign | 0 | spindle cell type | wt KIT and PDGFRα |
| 63 | m | 55 | stomach | 0.3 | benign | 0 | spindle cell type | wt KIT and PDGFRα |
| 64 | m | 45 | stomach | 4.5 | benign | 0 | mixed cell type | wt KIT and PDGFRα |
| 65 | m | 76 | stomach | 3.2 | benign | 0 | spindle cell type | wt KIT and PDGFRα |
| 66 | m | 78 | stomach | 0.4 | benign | 0 | spindle cell type | wt KIT and PDGFRα |
| 67 | f | 58 | stomach | 2.0 | benign | 1 | mixed cell type | wt KIT and PDGFRα |
| 68 | m | 62 | stomach | 2.5 | benign | 1 | spindle cell type | wt KIT and PDGFRα |
| 69 | f | 38 | stomach | 3.0 | benign | 4 | spindle cell type | wt KIT and PDGFRα |
| 70 | m | 62 | small bowel | 2.0 | benign | 1 | spindle cell type | wt KIT and PDGFRα |
| 71 | f | 38 | stomach | 4.5 | benign | 0 | spindle cell type | wt KIT and PDGFRα |
| 72 | m | 67 | small bowel | 4.0 | uncertain | 0 | spindle cell type | wt KIT and PDGFRα |
| 73 | m | 54 | stomach | 6.5 | uncertain | 2 | mixed cell type | wt KIT and PDGFRα |
| 74 | m | 26 | stomach | 8.0 | uncertain | 0 | spindle cell type | wt KIT and PDGFRα |
| 75 | f | 67 | small bowel | 13.0 | malignant | 0 | mixed cell type | wt KIT and PDGFRα |
| 76 | f | 60 | small bowel | 8.0 | malignant | 0 | spindle cell type | wt KIT and PDGFRα |
| 77 | f | 65 | recurrence | ND | malignant | 12 | spindle cell type | wt KIT and PDGFRα |
| 78 | f | 68 | stomach | 22.0 | malignant | 7 | epithelioid cell type | wt KIT and PDGFRα |
| 79 | m | 50 | small bowel | 10.0 | malignant | 0 | spindle cell type | wt KIT and PDGFRα |
| 80 | f | 77 | stomach | 11.0 | malignant | 2 | spindle cell type | wt KIT and PDGFRα |
| 81 | m | 68 | small bowel | 15.0 | malignant | 3 | mixed cell type | wt KIT and PDGFRα |
| 82 | m | 50 | peritoneum | 2.5 | malignant | 90 | mixed cell type | wt KIT and PDGFRα |
| 83 | m | 68 | small bowel | 8.0 | malignant | 7 | spindle cell type | wt KIT and PDGFRα |
| 84 | f | 43 | small bowel | 20.0 | malignant | 2 | spindle cell type | wt KIT and PDGFRα |
| 85 | m | 57 | small bowel | 11.1 | malignant | 4 | spindle cell type | wt KIT and PDGFRα |
| 86 | m | 72 | small bowel | 8.0 | malignant | 10 | spindle cell type | wt KIT and PDGFRα |
| 87 | f | 39 | small bowel | 13.5 | malignant | 0 | mixed cell type | wt KIT and PDGFRα |
Abbreviations: m, male; f, female; φ, maximum diameter in cm; MIB-1 index, percentage of cells showing nuclear staining for MIB-1; MC, mitotic count (mitoses/50 HPFs); histomorphology; histomorphological subtype according to Fletcher et al13;
*
, DNA sequences in KIT exon 9 and 11, in PDGFRα exon 12 and 18; ND, no data available.