Table 3.
Cognitive function at each cognitive assessment
| Cognitive test (assessment) | Aspirin group | Placebo group | Mean difference* (95% CI) | |||
|---|---|---|---|---|---|---|
| No of participants | Adjusted mean (SE) | No of participants | Adjusted mean (SE) | |||
| Global score†: | ||||||
| First | 3215 | −0.01 (0.01) | 3162 | 0.00 (0.01) | −0.01 (−0.04 to 0.02) | |
| Second | 2873 | 0.07 (0.01) | 2819 | 0.06 (0.01) | 0.01 (−0.03 to 0.04) | |
| Third | 2630 | 0.02 (0.01) | 2596 | 0.02 (0.01) | 0.00 (−0.04 to 0.04) | |
| Verbal memory score‡: | ||||||
| First | 3215 | −0.01 (0.01) | 3162 | 0.01 (0.01) | −0.02 (−0.05 to 0.02) | |
| Second | 2873 | 0.13 (0.01) | 2819 | 0.13 (0.01) | 0.00 (−0.04 to 0.04) | |
| Third | 2630 | 0.09 (0.02) | 2596 | 0.11 (0.02) | −0.02 (−0.06 to 0.02) | |
| TICS test: | ||||||
| First | 3208 | 34.18 (0.05) | 3154 | 34.26 (0.05) | −0.08 (−0.22 to 0.05) | |
| Second | 2871 | 34.07 (0.05) | 2817 | 34.12 (0.05) | −0.05 (−0.20 to 0.10) | |
| Third | 2630 | 34.09 (0.06) | 2596 | 34.11 (0.06) | −0.02 (−0.19 to 0.14) | |
| Category fluency test: | ||||||
| First | 3202 | 17.58 (0.09) | 3151 | 17.46 (0.09) | 0.12 (−0.13 to 0.36) | |
| Second | 2871 | 18.13 (0.10) | 2817 | 18.02 (0.10) | 0.12 (−0.15 to 0.39) | |
| Third | 2629 | 17.76 (0.10) | 2596 | 17.38 (0.10) | 0.37 (0.10 to 0.65) | |
TICS=telephone interview of cognitive status.
*From longitudinal linear models by treatment assignment of mean cognitive performance.
†Composite of five tests: TICS, immediate and delayed recalls of east Boston memory test, delayed recall of 10 word list, and category fluency.
‡Composite of four tests: immediate and delayed recalls of both 10 word list and east Boston memory test.