Table 1.

Main producers and Effects of IL-12, IL-15 and IL-7

Cytokine	Produced by	Effects
IL-12	Macrophages Monocytes Dendritic cells B lymphocytes T lymphocytes	-increased secretion of IFN-γ and TNF-α by NK and Th cells -induction of Th1 from Th0 and generation of CTLs -increased secretion of IL-2 -elevated serum IgG and mucosal IgA
IL-15	Macrophages Dendritic cells Keratinocytes Epithelial cells	-induces T cell proliferation -protects from apoptosis -promotes CTL memory -stimulates proliferation of intestinal epithelial cells -chemotactic for T lymphocytes -induces differentiation of sIgM1, IgA2 and sIgM2sIgA1 B cells into IgA-producing cells in mucosa
IL-7	Non-hematopoetic stromal cells of bone marrow, thymus, lymphoid organs, mucosal lymphoid tissues, skin and liver	-development, proliferation and survival of memory CD4+ and CD8+ T cells -key-regulator of transition of effector T cells to memory T cells -long term survival of CD8 memory T cells