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. 2003 Mar;162(3):907–923. doi: 10.1016/S0002-9440(10)63886-2

Figure 8.

Figure 8.

Representative images (serial sections) of an enlarged region of the detrusor muscle show the lack of remarkable PAR-1 (A), PAR-2 (B), and PAR-3 (C) immunolabeling in the same area with prominent PAR-4 (D) immunolabeling of the nerve fibers (arrowheads). For control, lack of immunolabeling is observed using the α-SMA (E) and negative control (F) antibodies in the identical areas of the nerve fibers (arrowheads). Additional representative images of consistently intense PAR-4 immunolabeling in the nerve bundles and plexus cell bodies (arrowheads) are presented in the mouse bladder throughout the detrusor muscle layer (G), which did not vary in the acute LPS (left), chronic LPS (middle), and Ag-challenged (right) inflammation conditions. Original magnifications: ×600 (A–F); ×300 (G).