Table 1.
Distribution of PAR Immunoreactivity in Mouse Bladder Tissues
| PAR | Cell type | Saline-control | Acute LPS | Chronic LPS | Ag-challenged | Substance P-challenged |
|---|---|---|---|---|---|---|
| PAR1 | Fibroblasts | −/+ | −/+ | +++ | −/+ | −/+ |
| Detrusor muscle | +/++ | +++ | −/+ | +++ | −/+ | |
| Urothelium | ++ | −/+ | ++ | +/++ | −/+ | |
| PAR2 | Fibroblasts | − | −/+ | ++ | −/+ | −/+ |
| Detrusor muscle | +/++ | +++ | −/+ | +++ | −/+ | |
| Urothelium | ++/+++ | + | ++ | +/++ | + | |
| PAR3 | Fibroblasts | −/+ | −/+ | ++ | −/+ | −/+ |
| Detrusor muscle | −/+ | ++/+++ | −/+ | ++/+++ | −/+ | |
| Urothelium | ++/+++ | ++ | ++ | ++/+++ | + | |
| PAR4 | Fibroblasts | −/+ | + | ++ | −/+ | + |
| Detrusor muscle | −/+ | ++/+++ | −/+ | ++ | −/+ | |
| Urothelium | ++ | +/++ | ++ | ++/+++ | +/++ |
No detectable PAR immunoreactivity (−); weak, light brown immunoreactivity (1+); moderate brown immunoreactivity (2+); intense, dark brown immunoreactivity (3+); double scores (i.e. ++/+++) indicate mixed population of cells.