Table 2.
Expression of K1, K2e, and K10 in Normal and Diseased Oral Epithelia*
| Case no. | Disease | Site | Expression of keratin proteins in suprabasal compartment or tumour islands | ||
|---|---|---|---|---|---|
| K2e | K1 | K10 | |||
| O-1 | Normal | Buccal mucosa | − | +/− | − |
| O-2 | Normal | Buccal mucosa | − | + | + |
| O-3 | Normal | Ventral tongue | +/− | + | + |
| O-4 | Normal | Ventral tongue | +/− | +/− | + |
| O-5 | Normal | Gingiva | +/− | + | ++ |
| O-6 | Normal | Gingiva | + | + | + |
| O-7 | Keratosis | Buccal mucosa | − | ++ | + |
| O-8 | Keratosis | Buccal mucosa | +/− | ++ | ++ |
| O-9 | Keratosis | Buccal mucosa | +/− | ++ | + |
| O-10 | Keratosis | Lingual mucosa | + | +++ | +++ |
| O-11 | Keratosis | Dorsal tongue | + | + | + |
| O-12 | Keratosis | Lateral tongue | − | +/− | − |
| O-13 | Lichen planus | Buccal mucosa | − | + | ++ |
| O-14 | Lichen planus | Buccal mucosa | − | ++ | ++ |
| O-15 | Lichen planus | Lingual mucosa | − | +/− | +/− |
| O-16 | Lichen planus | Gingiva | − | + | + |
| O-17 | Lichen planus | Gingiva | − | ++ | ++ |
| O-18 | Mild dysplasia | Verical tongue | +/− | ++ | ++ |
| O-19 | Mild dysplasia | Verical tongue | +++ | +++ | +++ |
| O-20 | Moderate dysplasia | Buccal mucosa | +/− | +/− | ++ |
| O-21 | Moderate dysplasia | Floor of mouth | − | + | + |
| O-22 | Moderate dysplasia | Labial mucosa | +/− | + | + |
| O-23 | Severe dysplasia | Lateral tongue | +/− | +++ | +++ |
| O-24 | Severe dysplasia | Soft palate | +/− | ++ | + |
| O-25 | WDSCC | Gingiva | − | ++ | − |
| O-26 | WDSCC | Alveolar ridge | +/− | +++ | ++ |
| O-27 | MDSCC | Alveolar ridge | − | +/− | +/− |
| O-28 | MDSCC | Floor of mouth | − | − | +/− |
| O-29 | PDSCC | Ventral tongue | − | − | − |
| O-30 | PDSCC | Lateral tongue | − | − | − |
| O-31 | PDSCC | Floor of mouth | − | − | −+/− |
*To show individual variations in keratin gene expression for a clinical situation all cases used in this study are listed here.
SCC, Squamous cell carcinoma; WD, well-differentiated; MD, moderately differentiated; PD, poorly differentiated; B, basal and LS lower 1/3 of the suprabasal compartment (2 to 5 layers). No immunostaining for protein (−), <5% cells positive (+/−), 10 to 30% cells positive (+), 40 to 70% cells positive (++), 80 to 100% cells positive (+++).