Figure 3.

The anti-proliferative response to heparin is variable from patient to patient. Exponentially growing myometrial (Myo) and leiomyoma (Fib) SMCs were treated with 10% FCS in the presence or absence of NAC heparin (10 to 300 μg/ml) for 2 days. Cells were counted on a Coulter Counter. A: Average of data from eight patients. B: Matched pair data from the same eight patients. Solid lines represent myometrial SMCs and dashed lines represent leiomyoma SMCs. Each different color represents a different patient, and the color code for patients is the same as that for Tables 1 and 2 ▶ . SEM for values in B are shown in Table 1 ▶ . Negative values indicate stimulation of proliferation when compared to 10% FCS control.