Table 3.
Mean Arterial Pressure (MAP), Portal Pressure (PP), Cardiac Output (CO), Total Peripheral Resistance (TPR), Heart Rate (HR), Stroke Volume (SV), Pulsatile Pressure (PuP), and Arterial Compliance (AC) in Control and Cirrhotic Rats Receiving Vehicle or Chronically Treated with L-NAME (0.5 mg.kg−1)
| Control rats | Cirrhotic rats | |||
|---|---|---|---|---|
| Vehicle (n = 12) | L-NAME (n = 12) | Vehicle (n = 11) | L-NAME (n = 11) | |
| MAP (mm Hg) | 121 ± 1 | 132 ± 3† | 94 ± 3¶ | 106 ± 2† |
| PP (mm Hg) | 5.6 ± 0.2 | 6.2 ± 0.2 | 12.6 ± 1.0¶ | 12.7 ± 1.3§ |
| CO (ml/min) | 199 ± 8 | 167 ± 11* | 311 ± 13¶ | 306 ± 20¶ |
| TPR (mm Hg · min · ml−1) | 0.63 ± 0.03 | 0.78 ± 0.06* | 0.30 ± 0.01¶ | 0.37 ± 0.02*¶ |
| HR (beat/min) | 355 ± 15 | 348 ± 22 | 315 ± 21 | 362 ± 14 |
| SV (ml/beat) | 0.59 ± 0.03 | 0.71 ± 0.13 | 1.17 ± 0.12¶ | 0.86 ± 0.05* |
| PuP (mm Hg) | 13.8 ± 0.8 | 12.1 ± 1.2 | 10.9 ± 1.3 | 13.5 ± 1.1 |
| AC (ml/mm Hg) | 0.046 ± 0.004 | 0.060 ± 0.010 | 0.140 ± 0.027§ | 0.070 ± 0.010* |
*, P < 0.05;
†, P < 0.01; compared with vehicle rats.
§, P < 0.01;
¶, P < 0.001 compared with control rats receiving the same treatment.