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Caudal Vertebra Number Displaying First Signs of Blood Vessel or Osteoclast Invasion
| MMPI | Angiogenesis | Osteoclastogenesis |
|---|---|---|
| Control (vehicle) | 16 ± 0.3† | 18 ± 0.1 |
| CH5902 | 12 ± 1.2* | 12 ± 1.0* |
| CH3921 | 10 ± 0.9*† | 18 ± 0.7 |
Data show angiogenesis and osteoclastogenesis, respectively, after 4 days of treatment with MMPIs (60 μg/mouse/day).
*P ≤ 0.001 (vs. control animals).
†, P ≤ 0.005 (angiogenesis vs. osteoclastogenesis in same animal), n = 6.
