Table 2.
Expression Pattern of Transferrin and KS-Bearing Thyroglobulin/Transferrin Isoforms in Healthy and Diseased Thyroid Tissues*
| Tissue | Component | |
|---|---|---|
| KS-bearing thyroglobulin/transferrin isoforms | Pan-transferrin | |
| Healthy thyroids | 0/10 | 0/10 |
| Nodular goiters | 1/48 (F-1)† | 3/20 (H-3) |
| Graves’ disease | 0/20 | 0/10 |
| Hashimoto’s thyroiditis | 2/11 (F-2) | 2/11 (H-2) |
| Follicular adenoma | 2/60 (F-2) | 3/26 (F-1, H-2) |
| PTC | 115/115 (F-8, H-20, W-87) | 35/45 (W-29, H-4, F-2) |
| PTC metastases‡ | 18/18 (F-1, H-2, W-15) | N.D. |
| Follicular carcinoma | 11/52 (F-7; H-4) | N.D. |
| Medullary carcinoma | 0/10 | N.D. |
| Anaplastic carcinoma | 0/5 | N.D. |
* The data refer to number of positive cases/out of the total analysed.
† The letter code and the adjacent number indicated within brackets refer to how many cases, out of the total analysed for each tissue type, exhibited the three patterns adopted for the semi-quantitative evaluation of the immunohistochemical stainings (ie, F, focal staining; H, heterogeneous staining; W, widespread staining; see Materials and Methods), which are based upon the relative number of positive cells detected in each lesion.
‡ Refers to lymphonodal metastases disclosed in PTC patients.