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Immunohistochemical staining with antibody to activated p70 S6 kinase (T421/S424) in brains with different degrees of neurofibrillary degeneration according to Braak’s staging criteria. 28 Following the sequence of neurofibrillary degeneration (a to d, same as in Figure 2 ▶ ) from normal control to Stage V/VI, antibody to p70 S6 kinase (T421/S424) showed progressively increased numbers of tangle-like inclusions and granular structures. Bars in 3, 100 μm; bars in insets, 10 μm.
