Skip to main content
. 2003 Aug;163(2):591–607. doi: 10.1016/S0002-9440(10)63687-5

Figure 6.

Figure 6.

Levels of p70 S6 kinase and tau, and their correlations in human brain homogenates. Levels of active p70 S6 kinases (T389, T421/S424), total tau (labeled by R134 days), and PHF-tau (labeled by PHF-1 or AT8) were significantly increased in AD as compared with control (A and B). Levels of total p70 S6 kinase and normal tau (labeled by Tau-1) did not differ significantly between AD and controls (A and B). A and B: Mean ± SEM of 13 control and 22 AD cases. * indicates P < 0.05, and *** indicates P ≤ 0.001. The Pearson correlation analyses showed that levels of total p70 S6 kinase and active p70 S6 kinase (T421/S424) rather than active p70 S6 kinase (T389) showed significant correlations with total tau and PHF-tau (labeled by PHF-1 or AT8) in AD homogenates (C, D, and E; Table 4 ▶ ). Immunoreactivities of p70 S6 kinase and tau are presented as percentage of the OD values of control cases per 2 μg protein. ▴, AD cases and •, control individuals.