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. 2003 Aug;163(2):423–432. doi: 10.1016/S0002-9440(10)63672-3

Figure 7.

Figure 7.

Expression of ATM in the malignant cells of Hodgkin’s disease. HRS cells from the majority of cases lacked detectable ATM expression. a: A representative ATM-negative HD tumor. b: Dual-labeling of ATM (purple) with CD30 (brown), confirming the absence of ATM expression in the malignant population in this case. d: Strong expression of ATM in the HRS cell of a tumor classified as ATM-positive. e: Expression of ATM (purple) in CD30-positive (brown) malignant cells from this case. We also observed differences in the phenotype of the malignant cells between ATM-positive and ATM-negative HD cases; thus with one exception, ATM-negative tumors either did not express CD138 or only expressed this marker at low levels in malignant cells (c), whereas ATM-positive HRS cells strongly expressed CD138 (f).