Table 1.
ATM Expression in B-Lymphoid Tumors
| Tumor | No. ATM-positive cases | |
|---|---|---|
| Diffuse large B-cell lymphoma | 11/47 | |
| Follicular lymphoma | 19/59 | |
| CD10-positive | 7/41* | |
| CD10-negative | 11/14 | |
| Mantle cell lymphoma | 7/15 | |
| Chronic lymphocytic leukemia† | 32/42 | |
| Wild-type ATM | 15/15 | |
| Mutant ATM | 0/2 | B-CLL1 1058delGT; 5464G→A(E1822Q) |
| B-CLL2 G1048T(A350T); T1055C(I352T) | ||
| 29/31 | ||
| Hodgkin’s disease (classic) | 5/25 | |
| CD138-positive | 5/6 | |
| CD138-negative | 0/19 | |
| EBV status‡ | ||
| (−) | 1/10 | |
| (+) | 3/14 | |
| Subtype | ||
| MC | 2/12 | |
| NS | 2/11 | |
| Lymphocyte-rich classic HD | 1/2 | |
| Age | ||
| <15 years | 1/6 | |
| 15 and over | 4/19 |
*CD10 status not determinable in four cases.
†ATM status had previously been determined for these CLL tumors.
‡EBV status not available for one ATM-positive case.