Figure 3.

Effect of E-cadherin expression on in vitro cell invasion. Analysis of the invasive properties of E-cadherin-transfected clones and vector-transfected clones in a modified Boyden chamber invasion assay. The specific synthetic MMP inhibitor BB-94 (BB94) was used to demonstrate that invasiveness of vector-transfected clones was MMP dependent. Results are expressed as the mean of three different experiments ± SD. Thirty fields (×400) were counted on each filter (**, P < 0.01; *, P < 0.05).