Table 3.
Pathology | Patient 1 | Patient 5 | Patient 6 | Patient 10* | Patient 11 |
---|---|---|---|---|---|
Duration of antibiotic treatment in relation to time of death | 82 hours | 11 hours | 3 hours | 55 hours | 95 hours |
Skin lesions | None | Dermal hematoma | None | None | None |
Pleural fluid† | R: >1000 cc | R: 1300 cc | R: 250 cc | R: 2,500 cc | R: 1,000 cc |
L: >1000 cc | L: 700 cc | L: 500 cc | L: 1,000 cc | L: 800 cc | |
Mediastinal lymph nodes | Hemorrhage, necrosis, effacement | Hemorrhage, necrosis, immunoblasts, neutrophils | Hemorrhage, necrosis, immunoblasts, neutrophils | Hemorrhage | Hemorrhage, necrosis, immunoblasts, neutrophils |
Pleurae and interhilar septae | Hemorrhage | Hemorrhage, inflammation | Hemorrhage | Inflammation | |
Lung parenchyma | Focal hyaline membranes | Unremarkable | Prominent intra-alveolar macrophages | Prominent intra-alveolar macrophages | Peribronchial inflammation, intra-alveolar edema |
Spleen | Necrosis | Congestion, immunoblasts | Congestion, immunoblasts, neutrophils | Congestion | |
Intestine | Focal hemorrhage | Unremarkable | Focal hemorrhage and inflammation | Unremarkable | |
Gram-positive bacilli | None | Present in all tissues | Present in all tissues | Present in lymph node | None |
Location of bacilli with Steiner stain | Thoracic and abdominal tissues | Thoracic and abdominal tissues | Thoracic and abdominal tissues | Mediastinal lymph node | Mediastinal tissues, lung |
IHC staining in thoracic tissues‡ | Abundant | Abundant | Abundant | Abundant | Abundant |
IHC staining in liver and spleen | Present | Present | Present | Negative |
*Limited amounts of tissue available for study.
†, Amount of pleural fluid on right (R) and left (L) pleural cavity.
‡, Thoracic tissues include mediastinal lymph nodes and soft tissues and pleurae.