Figure 6.

Immunodetection of Fli1 in skin from healthy individuals and uninvolved and involved skin from patients with SSc. Positively stained fibroblasts and endothelial cells are present in healthy skin (a, b) (original magnifications, ×400; scale bar, 100 μm). Thick arrow points to Fli1-positive fibroblasts, an asterisk indicates endothelial cell; c and d, e and f, and g and h involved and uninvolved skin sections from patients with SSc. Note absence of Fli1 in fibroblasts (thin arrow points to Fli1-negative fibroblast) and in some endothelial cells (asterisk) in SSc skin. k: Percentage of Fli-1-positive fibroblasts in SSc and healthy skin. At least 100 fibroblasts were counted for each specimen.