Table 2.

Abundance of HCV Genomic and Replicative-Intermediate RNA Molecules in Infected Liver Tissues

Specimen	Average AII of total HCV RNA signals particles per image		Average HCV RNA molecules per g of liver tissue*		Ratio
	Genomic	Replicative-intermediate	Genomic	Replicative-intermediate
A-1	44.5 × 104	2.2 × 104	4.2 × 108	2.1 × 107	20
A-2	103.2 × 104	7.2 × 104	9.7 × 108	6.8 × 107	14
B-1	14.0 × 104	3.6 × 104	1.3 × 108	3.4 × 107	4
B-2	58.1 × 104	5.5 × 104	5.4 × 108	5.1 × 107	11
C	71.1 × 104	5.6 × 104	6.7 × 108	5.3 × 107	13
D	23.4 × 104	5.5 × 104	2.2 × 108	5.1 × 107	4
E	135.4 × 104	47.3 × 104	1.3 × 109	4.4 × 108	3

*HCV RNA molecules per g of liver tissue for each patient is derived from our measurement of HCV RNA molecules per ml of liver tissue, assuming the density of adult liver is 1 g/ml.