Figure 6.

Effect of impaired IGF-I receptor function on pancreatic tumor growth in vivo. In an orthotopic tumor model, pcDNA- or IGF-IR DN-transfected L3.6pl cells (250,000 cells in 50 μl) were injected into the pancreas of nude mice, and 29 days later the mice were killed and the pancreatic tumors excised. A: Tumors weighed less in the IGF-IR DN group versus in the pcDNA group (*, P < 0.01). B: Inhibition of IGF-IR function significantly reduced pancreatic tumor volumes (width² × length × 0.5) (*, P < 0.01; Mann-Whitney U-test). Data are presented as means ± SEM. C: Representative pancreatic tumors (arrows) from each group.