Table 1.
Gender | Wild type | FcγRIIb−/− | TSLP transgene | FcγRIIb−/− and TSLP transgene | |
---|---|---|---|---|---|
Body weight (g) | ♀ | 19.1 ± 0.4 | 20.1 ± 0.6 | 17.6 ± 1.2 | 16.5 ± 1.3 |
♂ | 30.9 ± 1.0 | 29.6 ± 0.7 | 27.1 ± 1.0* | 25.5 ± 1.5 | |
Kidney weight (g) | ♀ | 0.25 ± 0.01 | 0.28 ± 0.01 | 0.27 ± 0.02 | 0.28 ± 0.03 |
♂ | 0.38 ± 0.02 | 0.39 ± 0.02 | 0.37 ± 0.02 | 0.47 ± 0.04 | |
Spleen weight (g) | ♀ | 0.08 ± 0.00 | 0.10 ± 0.01 | 0.32 ± 0.05** | 0.49 ± 0.07 |
♂ | 0.09 ± 0.01 | 0.10 ± 0.01 | 0.40 ± 0.03*** | 0.97 ± 0.09### | |
Liver weight (g) | ♀ | 0.86 ± 0.01 | 1.04 ± 0.05 | 1.17 ± 0.06 | 1.33 ± 0.09 |
♂ | 1.39 ± 0.07 | 1.42 ± 0.03 | 1.48 ± 0.04 | 1.96 ± 0.03## | |
Lung weight (g) | ♀ | 0.15 ± 0.01 | 0.18 ± 0.00 | 0.27 ± 0.02** | 0.36 ± 0.04 |
♂ | 0.18 ± 0.01 | 0.18 ± 0.01 | 0.33 ± 0.01*** | 0.54 ± 0.07# | |
Heart weight (g) | ♀ | 0.12 ± 0.01 | 0.14 ± 0.01 | 0.10 ± 0.01 | 0.14 ± 0.01# |
♂ | 0.15 ± 0.01 | 0.17 ± 0.01 | 0.17 ± 0.01 | 0.18 ± 0.01 |
Body and organ weight in different experimental groups at time of sacrifice (day 50 for females and day 120 for males). Data expressed as mean ± standard error of the mean. Statistical significances compared to wild-type controls
(*, P < 0.05;
**, P < 0.01;
***, P < 0.001) or compared to TSLP transgenic animals
(#, P < 0.05;
##, P < 0.01;
###, P < 0.001).