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. 2003 Sep;163(3):1021–1031. doi: 10.1016/S0002-9440(10)63462-1

Figure 3.

Figure 3.

Double-labeling of AD NFTs at various stages with n847 and 17024/Thio-S. A: The n847 IR co-localizes with 17024 IR NFTs. Shown in a, b, and c of A are representative images of types 2, 3 and 4 n847 IR cells, respectively. Co-localization of staining is seen in the merged images and by confocal microscopy. Bars, 10 μm. B: The n847 IR is evident in pre-tangles. To identify neurons containing nitrated NFTs, adjacent sections were labeled with combination of n847 and 17024 (section 1) or Thio-S and 17024 (section 2) as described in the text. Thio-S-positive and -negative neurons are indicated by arrowhead and arrow, respectively. C: Double-label studies of NFTs by n847 and Thio-S. Four representative labeling patterns of Thio-S are shown: (a) none; (b) uniformly moderate; (c) mixed intense and moderate; (d) uniformly intense. Note that the n847 IR decreases as Thio-S labeling increases. Bars, 10 μm.