Table 1.
Frequency of Inflammatory Lesions in the Salivary and Lacrimal Glands in Transferred C57BL/6 and SCID Mice Treated with Ovx
| Treatment | No. of mice | No. of mice with lesions* | ||
|---|---|---|---|---|
| Submandibular | Parotid | Lacrimal | ||
| 4 weeks after transfer (C57BL/6) | ||||
| Ovx alone† | 5 | 0/5 | 0/5 | 0/5 |
| Sham | 5 | 0/5 | 0/5 | 0/5 |
| Ovx+transfer‡ | 7 | 5/7 | 7/7 | 6/7 |
| Sham+transfer | 7 | 0/7 | 0/7 | 0/7 |
| Ovx+transfer (OVA)§ | 5 | 0/5 | 0/5 | 0/5 |
| 8 weeks after transfer (C57BL/6) | ||||
| Ovx alone† | 5 | 0/5 | 0/5 | 0/5 |
| Sham | 5 | 0/5 | 0/5 | 0/5 |
| Ovx+transfer§ | 7 | 6/7 | 7/7 | 7/7 |
| Sham+transfer | 7 | 0/7 | 0/7 | 0/7 |
| Ovx+transfer (OVA)§ | 5 | 0/5 | 0/5 | 0/5 |
| 8 weeks after transfer (SCID) | ||||
| Ovx alone† | 5 | 0/5 | 0/5 | 0/5 |
| Sham | 5 | 0/5 | 0/5 | 0/5 |
| Ovx+transfer‡ | 7 | 5/7 | 6/7 | 6/7 |
| Sham+transfer | 7 | 0/7 | 0/7 | 0/7 |
*Histological evaluation for frequency of inflammatory lesions in the salivary and lacrimal glands was done according to the method proposed by White and Casarett. 30
†Female C57BL/6 (B6) and SCID mice were ovariectomized (Ovx) at 4 weeks of age.
‡Ovx-B6 and SCID mice were transferred intraperitoneally with 5 × 106 α-fodrin-reactive T cells at 6 weeks of age.
§Ovx-B6 mice were transferred with 5 × 106 OVA-reactive T cells. α-fodrin-reactive T cells were obtained from B6 or BALB/c mice as described in detail in the text.