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PAI-1 mRNA expression by in situ hybridization. PAI-1 mRNA expression was marked in WT UUO, contrasting very little expression in β6−/− UUO. After Ang II or Aldo or combination infusion, PAI-1 mRNA expression was similar in β6−/− UUO and WT UUO, correlating with similar degree of collagen accumulation (n = 3 to 6 for each group). Original magnifications, ×40.
