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Expression of MEK1* in cells overexpressing cyclin D1 and CDK4. Serum-starved cells from three subclones coexpressing cyclin D1, CDK4, and inducible MEK1* were stimulated with ZnSO4 or FBS for 12 hr. Cell lysates were assayed for expression of MEK1*, cyclin D1, and CDK4 by immunoblotting (A), cyclin D1-CDK4 complex formation by immunoprecipitation with CDK4 antibody followed by immunoblotting with cyclin D1 antibody (B), and CDK4-associated RB kinase activity (C).
