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. 2003 Oct;163(4):1653–1662. doi: 10.1016/S0002-9440(10)63522-5

Figure 1.

Figure 1.

Accelerated injury in FGF1(−/−)FGF2(−/−) livers after acute CCl4 treatment. A: Plasma ALT levels after acute CCl4 treatment. ALT activity was measured using the GP-Transaminase kit (no. 505-P; Sigma, St. Louis, MO) as described. 15 Values were the mean ± SD (n = 4 mice). Significance of differences between FGF1(−/−)FGF2(−/−) and WT mice at 24, 38, and 48 hours was P < 0.05. B: Hepatocyte DNA synthesis after acute CCl4 treatment. DNA synthesis was assessed by BrdU incorporation as described in Materials and Methods. Values were the mean ± SD (n = 4 mice). Significance of differences between FGF1(−/−)FGF2(−/−) and WT mice at 38 and 48 hours was P < 0.02. C: Liver-to-total body weight ratio after acute CCl4 treatment. Livers were excised and weighed as described. 17 Values were the mean ± SD (n = 4 mice). Significance of the difference between FGF1(−/−)FGF2(−/−) and WT livers was P > 0.05 at all time points.