Figure 7.
Decreased fibrosis in FGF1(−/−)FGF2(−/−) livers after chronic CCl4 administration. A: The indicated type mice were subjected to chronic CCl4 treatment for 21 days as described in Materials and Methods. Livers were excised; tissue sections were prepared and stained with H&E (top) or Sirius Red (bottom). B: Quantitative analysis of collagen in liver sections. Total liver collagen in sections of WT or FGF1(−/−)FGF2(−/−) mice was quantitated as described in Materials and Methods. Values are the mean ± SD (n = 4 mice). Significance of differences between FGF1(−/−)FGF2(−/−) and WT mice at day 21 was P < 0.02. Original magnifications, ×60 (A).