Figure 1.
Outcome of eGFP-CVB CNS infection is dose-dependent, and changes dramatically within days of birth. A: Newborn BALB/c pups were inoculated i.c. with the indicated doses of eGFP-CVB, or with medium alone (mock), and their survival over a 30-day period is shown. B: Mice of the indicated ages were inoculated i.c. with eGFP-CVB (2 × 107 pfu) and observed for survival over a 30-day period. C: Newborn pups were infected with eGFP-CVB (2 × 105 pfu, i.c.) and, at the indicated time points post-infection, mice were sacrificed, the brains, hearts, and pancreata were harvested, and viral titers were determined.