Hemodynamics and ventricular weights were measured in control mice (C) or eNOS-GFPtg mice (Tg) before and after addition of L-NAME. a: Mean aortic pressure. b: Heart rate. c: Mean aortic blood flow. d: Systemic vascular resistance. e: Pulmonary artery pressure. f: Ventricular wet weights. g: Ventricular dry weights. a to d: n = 10 (C), n = 9 (Tg). e: n = 8 (C), n = 6 (Tg). f to g: n = 20 (C), n = 12 (Tg). *, P < 0.05 versus corresponding controls; †, P < 0.05 versus corresponding baseline before addition of L-NAME; ‡, P < 0.05 Δ in C versus Δ in Tg (Δ produced by addition of L-NAME).