Table 3.

Forced-Titration Schedule for Insulin Glargine[29]

Start with 10 U/day basal insulin dose and adjust weekly
Self-monitored FPG*	↑ in insulin dose (U/day)
≥ 180 mg/dL (9.9 mmol/L)	8
≥ 140 but < 180 mg/dL (≥ 7.7 but < 9.9 mmol/L)	6
≥ 120 but < 140 mg/dL (≥ 6.6 but < 7.7 mmol/L)	4
≥ 100 but < 120 mg/dL (≥ 5.5 but < 6.6 mmol/L)	2

FPG = fasting plasma glucose

^*Two consecutive days with no episodes of severe hypoglycemia or plasma glucose levels < 72 mg/dL (4.0 mmol/L).

Small ↓ (2–4 U/day adjustment) in dose allowed when self-monitored plasma glucose level is < 56 mg/dL (3.1 mmol/L) or severe hypoglycemic episode occurs. Individual titration schedules should be implemented to minimize risk of hypoglycemia.