Skip to main content
. 2006 Oct 5;8(4):4.

Table 1.

Studies Used in the Analysis

Study Drug Mean Dose (mg/d) Mean Dose (mg/kg/d) Method of Dosing N in Drug Group N in Placebo Group Mean Age % Male
Conners[36] MPH 22 .82 Best 20 20 12 95
Taylor[37] MPH DNP DNP Best 37 37 9 100
Klorman[38] MPH 22.3 .76 Best 44 44 9 84
Conners[12] Bupropion DNP 6 Best 52 20 9 90
Schachar[39] MPH 31.9 1.2 Best 37 29 8 77
Manos[40] MAS 10.6 DNP Best 42 42 10 79
Manos[40] MPH 19.5 DNP Best 42 42 10 79
Zeiner[35] MPH DNP .5 Best 36 36 9 100
Bostic[41] Pemoline 1.81 3 Best 21 21 14 86
Pliszka[42] MAS 12.5 .31 Best 20 18 8 DNP
Pliszka[42] MPH 25.2 .39 Best 20 18 8 DNP
James[33] MAS 10.3 .32 DNP 35 35 9 60
James[33] d-Amp 10.3 .32 DNP 35 35 9 60
James[33] d-Amp ER 10.3 .32 DNP 35 35 9 60
Wolraich[7] MPH 29.5 .9 Best 97 90 9 87
Wolraich[7] MPH OROS 34.3 1.1 Best 95 90 9 78
Michelson[20] Atomoxetine DNP 1.8 Fixed 82 83 11 72
Michelson[43] Atomoxetine DNP 1.3 Best 84 83 10 71
Biederman[44] Atomoxetine DNP 2 Best 31 21 10 0
Biederman[8] MAS XR 30 DNP Fixed 120 203 9 80
Greenhill[6] MPH MR 40.7 1.28 Best 155 159 9 83
Spencer[45] Atomoxetine 90 2 Best 49 47 10 81
Spencer[45] Atomoxetine 90 2 Best 53 45 10 81
Biederman[46] MPH-LA DNP DNP Best 63 71 9 77
Wigal[47] MPH 32.14 DNP Best 41 41 10 88
Wigal[47] d-MPH 18.25 DNP Best 42 41 10 88
Swanson[48] Modafinil 395.3 DNP Fixed 120 63 10 74
Biederman[49] Modafinil 382.5 DNP Fixed 120 63 10 74
Findling[50] MPH OROS 54 DNP Best 89 85 9 70
Findling[50] MTS 27 DNP Best 96 85 9 66
Pelham[51] MTS 31.6 DNP Fixed DNP DNP 10 87
Greenhill[52] Modafinil 297.5 DNP Best 128 66 10 73
Kelsey[53] Atomoxetine DNP 1.3 Best 126 60 10 71
Wilens[34] MPH OROS 53.6 DNP Best 87 90 15 80
Spencer[54]a MAS-XR 40 DNP Fixed 27 24 14 64
Spencer[54]b MAS-XR 40 DNP Fixed 26 28 14 64
Findling[55] MPH 30 DNP Best 120 39 10 79
Findling[55] MPH-MR 30 DNP Best 120 39 10 81

Note: Studies are listed more than once if they studied more than 1 drug or presented more than 1 independent trial of the same drug; MPH = methylphenidate; DNP = data not provided; MAS = mixed amphetamine salts; d-Amp = dextroamphetamine; d-Amp ER = dextroamphetamine extended release; MAS XR = mixed amphetamine salts-extended release; d-MPH = dexmethylphenidate; MPH MR = methylphenidate modified release; MPH-LA = methylphenidate long acting; MPH OROS = methylphenidate using osmotic-release oral system technology; MTS = methylphenidate transdermal system.

a

Severe ADHD group;

b

Mild ADHD Group (demographics not given separately for each group)