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. Author manuscript; available in PMC: 2007 May 14.
Published in final edited form as: Biochemistry. 2006 Apr 18;45(15):4808–4818. doi: 10.1021/bi052294c

Figure 7.

Figure 7

The conformations of loops L2 and L4 and their interactions with the flavin ring. (A) Stereoview of the flavin ring with L2 closed and L4 open. NH of Ala 62 from L2 is hydrogen bonded to the flavin O2, but NH of Asp120 interacts through an intervening water molecule. (B) Stereoview of the flavin ring with L2 open and L4 closed. The hydrogen bond between NH 62 and O2 is lost, but NH of Asp120 interacts directly with O2. In the complex of Glu28Gln MTHFR with CH3-H4folate, both loops are closed.