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. Author manuscript; available in PMC: 2008 Feb 1.
Published in final edited form as: Immunol Allergy Clin North Am. 2007 Feb;27(1):93–103. doi: 10.1016/j.iac.2006.11.002

Figure 3.

Figure 3

In vivo GFD inhibits IgE-mediated degranulation in transgenic mice expressing human FcεRIα. A. Dose-dependent inhibition of PCA by GFD. The labeled back skin sites were sensitized with cat allergic serum (1:5 dilution) for 4 hours, followed by the administration of: I, saline; II, 1 ng of GFD in 50 μl saline; III, 10 ng of GFD; and IV, 100 ng of GFD. B. Comparison of GFD and GE2 for their ability to inhibit PCA reactivity to human anti-Fel d1 IgE. The skin sites were sensitized with 1:5 diluted cat allergic serum, with the following treatment: I, saline injection 4 h later; II, 100 ng GFD 4 h later; III, 100 ng GFD simultaneously with serum; IV, 1 μg GE2 simultaneously with serum; V, 100 ng GE2 4 h later; VI, 100 ng GE2 simultaneously with serum. (Adapted from Zhu D, Kepley CL, Zhang K, et al. A Chimeric Human –Cat Fusion Protein Blocks Cat-induced Allergy, Nat Med. 2005; 11:446–9, with permission).