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. Author manuscript; available in PMC: 2008 Feb 1.
Published in final edited form as: Immunol Allergy Clin North Am. 2007 Feb;27(1):93–103. doi: 10.1016/j.iac.2006.11.002

Figure 4.

Figure 4

Subcutaneous (SQ) administration of GFD blocked Fel d1-induced allergic response in mouse model. A. Schematic diagram of the experimental protocol. B. Effect of GFD on blocking Fel d1-induced systemic allergic reactivity. The body temperature changes were assessed immediately after Fel d1 IT challenge (1 μg) with 5 minute intervals. The asterisk indicates a statistically significant difference between the two conditions. C. Effect of GFD on Fel d1-induced AHR. The airway resistance to methacholine challenge was assessed by a computer-controlled small animal FlexiVent® ventilator two days after IT Fel d1 challenge. The numbers represent the average values from three measurements of the airway resistance from a group of mice for each condition. D. Effect of GFD on Fel d1-induced pulmonary eosinophilic inflammation. Total and differential numbers of BAL fluid cells were counted. (Adapted from Zhu D, Kepley CL, Zhang K, et al. A Chimeric Human –Cat Fusion Protein Blocks Cat-induced Allergy, Nat Med. 2005; 11:446–9, with permission).