Table 1.

Primary structures of sea anemone toxins (based on Norton, 1991).

LD₅₀ (μ/kg)				Rat brain synaptosomes (K_D in nM)	Cockroach central nervous system (IC_M in nM)	EC₅₀ (nM) on rat heart muscle (Na, 1.5))	EC₅₀ (nM) on insect channel (para)
Toxin	Crab	Mice i.p.	Mice i.c.	Rat brain synaptosomes (K_D in nM)	Cockroach central nervous system (IC_M in nM)	EC₅₀ (nM) on rat heart muscle (Na, 1.5))	EC₅₀ (nM) on insect channel (para)
AFT-I	100–150	98				−2
AFT-II	100–150	450				2.62^*
ATX-I	2	>4000	236	7000
ATX-II	2	160	2.5	90–150	0.5–1.5^AA	15–49^*	− 10^*
ATX-V	5.2	19	1.6	50		2
AP-A	11	66	5.3	120		3
AP-B	39	8	0.2	35		2
BgII			0.4^A	9		500^*	5.5^*
BgIII			21^A	72		5100^*	1300^*
Rp-I	36	145	1.5	900		3000
Rp-II	15	4200	12	>100000		5000
Sh-I	0.5–3^**	>15000	116	40000^***		>8000

Results obtained from cloned channels expressed in ooytes and/or mammalian cells

^**

LD₅₀ varies with crab species

^***

K_D in crab is 14 nM.

i.c.v. injections

^AA

EC₅₀ in locus central nervous system in 6 nM, LD₅₀ in mice (S.C.) is 22 pmole/g and 2.5 pmole/g in B. Germanica.