Table 5.
Characterization methods using blood components
Blood component | Function characterized | Result for non-activated EC | Combination of molecules dominating response |
---|---|---|---|
Recalcified plasma | Fibrin generation | Long recalcification time | TF, TFPI, TM, AT |
Platelets | Platelet adhesion Platelet activation | Low platelet adhesion and spreading and low (serotonin) release | Prostacyclin, vWF, NO, PECAM |
Leukocytes | WBC adhesion WBC activation | Low adhesion and activation | V-CAM, I-CAM, E-selectin, PECAM |
Fibrin dissolution | Fibrinolysis | Functional EC will lyse clot | tPA, PAI-1 |
AT Antithrombin
TFPI Tissue factor pathway inhibitor
TM Thrombomodulin
TF Tissue factor
NO Nitric oxide
tPA Tissue plasminogen actiator
PAI-1 Plasminogen activator inhibitor type 1