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. Author manuscript; available in PMC: 2008 Apr 1.
Published in final edited form as: Mol Immunol. 2007 Jan 22;44(10):2659–2666. doi: 10.1016/j.molimm.2006.12.006

Table 1.

Analysis of strand bias in Somatic Hypermutation in various genes

Spectrum G→N C→N PGC1 A→N T→N PAT2
In vivo mammalian SHM:
VkOx1 0.31 0.23 0.11 0.32 0.14 0.0001
neo 0.21 0.17 0.52 0.40 0.22 0.02
gpt 0.23 0.30 0.65 0.25 0.22 0.32
globin 0.21 0.29 0.61 0.27 0.23 0.18
lambda 0.26 0.22 0.26 0.37 0.18 0.000005
MMjh4 intron 0.18 0.21 0.55 0.38 0.23 0.003
HSjh4 intron 0.27 0.23 0.54 0.33 0.17 0.02
msh2-/- 0.50 0.33 0.41 0.11 0.06 0.47
iota-/- 0.25 0.20 0.35 0.36 0.19 0.001
ung-/- 0.26 0.25 0.86 0.33 0.16 0.00004
ung-/-msh2-/- 0.39 0.60 0.002 <0.01 <0.01 1.00
In vitro mammalian SHM:
Ramos 0.41 0.37 0.26 0.12 0.10 0.88
AID-tg-hP1-5 0.37 0.45 0.52 0.11 0.07 0.43
BL2 0.71 0.21 0.0005 0.08 0.00 0.10
GFP 0.55 0.44 0.05 0.01 <0.01 0.59
In vivo non-mammalian SHM:
Chicken 0.30 0.16 0.14 0.40 0.14 0.05
Xenopus 0.38 0.54 0.31 0.03 0.05 0.73
Shark NAR 0.23 0.25 0.71 0.29 0.23 0.43
1

PGC represents the probability of absence of strand-bias at G,C bases.

2

PAT represents the probability of absence of strand-bias at A,T bases.

Underlined frequencies depict significant bias.