Table 1.
Analysis of strand bias in Somatic Hypermutation in various genes
| Spectrum | G→N | C→N | PGC1 | A→N | T→N | PAT2 |
|---|---|---|---|---|---|---|
| In vivo mammalian SHM: | ||||||
| VkOx1 | 0.31 | 0.23 | 0.11 | 0.32 | 0.14 | 0.0001 |
| neo | 0.21 | 0.17 | 0.52 | 0.40 | 0.22 | 0.02 |
| gpt | 0.23 | 0.30 | 0.65 | 0.25 | 0.22 | 0.32 |
| globin | 0.21 | 0.29 | 0.61 | 0.27 | 0.23 | 0.18 |
| lambda | 0.26 | 0.22 | 0.26 | 0.37 | 0.18 | 0.000005 |
| MMjh4 intron | 0.18 | 0.21 | 0.55 | 0.38 | 0.23 | 0.003 |
| HSjh4 intron | 0.27 | 0.23 | 0.54 | 0.33 | 0.17 | 0.02 |
| msh2-/- | 0.50 | 0.33 | 0.41 | 0.11 | 0.06 | 0.47 |
| iota-/- | 0.25 | 0.20 | 0.35 | 0.36 | 0.19 | 0.001 |
| ung-/- | 0.26 | 0.25 | 0.86 | 0.33 | 0.16 | 0.00004 |
| ung-/-msh2-/- | 0.39 | 0.60 | 0.002 | <0.01 | <0.01 | 1.00 |
| In vitro mammalian SHM: | ||||||
| Ramos | 0.41 | 0.37 | 0.26 | 0.12 | 0.10 | 0.88 |
| AID-tg-hP1-5 | 0.37 | 0.45 | 0.52 | 0.11 | 0.07 | 0.43 |
| BL2 | 0.71 | 0.21 | 0.0005 | 0.08 | 0.00 | 0.10 |
| GFP | 0.55 | 0.44 | 0.05 | 0.01 | <0.01 | 0.59 |
| In vivo non-mammalian SHM: | ||||||
| Chicken | 0.30 | 0.16 | 0.14 | 0.40 | 0.14 | 0.05 |
| Xenopus | 0.38 | 0.54 | 0.31 | 0.03 | 0.05 | 0.73 |
| Shark NAR | 0.23 | 0.25 | 0.71 | 0.29 | 0.23 | 0.43 |
PGC represents the probability of absence of strand-bias at G,C bases.
PAT represents the probability of absence of strand-bias at A,T bases.
Underlined frequencies depict significant bias.