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. 1999 Jul;155(1):315–324. doi: 10.1016/S0002-9440(10)65125-5

Figure 4.

Figure 4.

Photomicrographs of metastatic lesion and SCC with different grades. A: Metastatic lesion within lung from a transgenic rabbit that developed SCC. Notice the sheets of poorly differentiated neoplastic epithelial cells that have replaced lung, and the focal tumor necrosis. B: Cutaneous SCC from a transgenic rabbit that resembles grade II squamous cell carcinoma. Notice the clusters and cords of neoplastic epithelial cells with squamous differentiation separated by desmoplastic connective tissue. C: Cutaneous SCC from a transgenic rabbit that resembles grade III squamous cell carcinoma. Notice the sheets of poorly differentiated neoplastic epithelial cells with occasional intracellular keratin production. D: Cutaneous SCC from a transgenic rabbit that resembles grade IV squamous cell carcinoma. Notice the sheets of poorly differentiated neoplastic epithelial cells that show slight whorl patterns. H&E stain. Original magnification, ×50.