Table 2.

Characteristics of the Patients with Mutations of p53 in NSCLC

Case	Sex	Age (years)	Histology	Differentiation	T	N	Stage	Smoking	Mutation of p53		HSCORE of bcl-2	HSCORE of bax	Prognosis
									Codon	Base change			(months)
1	M	69	LA	Poorly	2	0	IB	+	132	AAG → AAT	0	20	74.3	Alive
2	F	60	AD	Moderately	2	0	IB	−	132	AAG → AGG	0	40	44.0	Dead
3	M	67	SQ	Poorly	3	0	IIB	+	132	AAG → AGG	70	80	65.9	Alive
4	M	55	SQ	Moderately	2	1	IIB	+	133	ATG → ATT	90	20	74.3	Alive
5	M	64	AD	Moderately	3	3	IIIB	+	133	ATG → ACG	0	180	14.4	Dead
6	M	50	LA	Poorly	2	0	IB	+	137	CTG → ATG	300	0	41.9	Alive
7	M	64	AD	Moderately	2	0	IB	+	137	CTG → ATG	0	40	38.2	Alive
8	M	74	SQ	Moderately	2	0	IB	+	143	GTG → GCG	90	80	66.9	Alive
9	M	62	AD	Well	2	2	IIIA	−	148	GAT → TAT	0	120	12.1	Dead
10	M	72	SQ	Poorly	2	0	IB	+	150	ACA → AAA	60	30	61.2	Alive
11	M	73	LA	Poorly	2	0	IB	+	150	ACA → AAA	0	80	40.2	Alive
12	M	55	AD	Moderately	4	3	IIIB	+	153	CCC → TCC	0	20	42.9	Dead
13	M	69	SQ	Poorly	2	0	IB	−	153	CCC → ACC	0	0	25.9	Dead
14	F	75	AD	Poorly	3	0	IIB	−	157	GTC → ATC	180	50	35.3	Alive
15	F	70	AD	Moderately	1	0	IA	−	157	GTC → ATC	0	150	75.7	Alive
16	M	70	LA	Poorly	2	0	IB	+	157	GTC → TTC	300	0	75.1	Dead
17	M	61	SQ	Moderately	1	3	IIIB	+	157	GTC → TTC	0	70	5.9	Dead
18	M	71	SQ	Moderately	3	2	IIIA	+	157	GTC → GAC	0	140	4.9	Dead
19	M	66	SQ	Moderately	1	0	IA	+	158	CGC → CAC	0	30	55.7	Alive
20	M	65	LA	Poorly	3	0	IIB	+	158	CGC → CTC	70	0	52.1	Alive
21	M	70	SQ	Poorly	3	0	IIB	+	158	CGC → CTC	160	5	78.9	Alive
22	F	58	AD	Moderately	1	0	IA	−	158	CGC → GGC	60	160	53.7	Alive
23	F	65	AD	Moderately	1	2	IIIA	−	161	GCC → GAC	0	100	42.1	Dead
24	M	63	SQ	Poorly	2	1	IIB	+	163	TAC → TAG	300	80	11.4	Dead
25	M	53	AD	Well	1	0	IA	+	163	TAC → TAT	0	200	61.7	Alive
26	M	68	LA	Moderately	2	0	IB	−	169	ATG → ATA	5	40	56.6	Alive
27	M	55	AD	Well	2	0	IB	+	175	CGC → AGC	100	80	45.8	Alive
28	M	69	SQ	Moderately	2	0	IB	+	175	CGC → AGC	0	40	70.8	Alive
29	F	60	SQ	Moderately	3	1	IIIA	+	175	CGC → AGC	50	30	56.1	Alive
30	F	59	AD	Poorly	1	2	IIIA	−	175	CGC → CAC	60	50	44.9	Alive
31	M	57	SQ	Moderately	2	0	IB	+	175	CGC → CAC	0	120	28.0	Alive
32	M	63	SQ	Moderately	2	0	IB	+	175	CGC → CAC	0	20	52.9	Alive
33	M	61	SQ	Poorly	3	2	IIIA	+	175	CGC → GGC	0	140	58.9	Alive
34	M	43	LA	Poorly	2	3	IIIB	−	213	CGA → TGA	0	70	5.8	Dead
35	M	65	SQ	Moderately	1	0	IA	+	228	GAC → AAC	0	0	16.1	Dead
36	F	61	AD	Well	1	1	IIA	−	228	GAC → GGC	0	120	69.9	Alive
37	M	56	SQ	Moderately	1	0	IA	+	235	AAC → TAC	200	60	39.3	Dead
38	F	68	SQ	Well	2	0	IB	+	239	AAC → ACC	0	45	14.2	Dead
39	M	69	SQ	Moderately	3	0	IIB	+	245	GGC → CGC	0	40	36.7	Alive
40	M	69	AD	Poorly	4	0	IIIB	+	245	GGC → CGC	100	10	14.8	Dead
41	M	50	SQ	Moderately	3	1	IIIA	+	245	GGC → TGC	0	40	15.9	Dead
42	M	70	AD	Moderately	3	2	IIIA	+	245	GGC → GGA	100	80	40.9	Alive
43	M	71	AD	Moderately	2	1	IIB	+	246	ATG → CTG	0	20	30.3	Dead
44	M	57	AD	Poorly	3	2	IIIA	+	248	CGG → CAG	0	0	10.2	Dead
45	M	60	AD	Poorly	1	0	IA	+	248	CGG → CAG	0	0	7.1	Dead
46	M	52	SQ	Moderately	2	1	IIB	+	248	CGG → CTG	160	30	86.0	Alive
47	M	72	AD	Well	2	3	IIIB	+	248	CGG → TGG	0	100	11.3	Dead
48	M	68	AD	Poorly	3	0	IIB	+	248	CGG → TGG	300	30	70.1	Alive
49	M	72	AD	Moderately	3	0	IIB	+	248	CGG → TGG	0	20	11.7	Dead
50	M	46	SQ	Poorly	2	1	IIB	+	248	CGG → TGG	70	0	36.7	Alive
51	F	66	AD	Poorly	3	0	IIB	+	249	AGG → AAG	0	80	35.1	Alive
52	M	82	AD	Moderately	1	0	IA	+	249	AGG → ATG	50	20	36.1	Alive
53	F	69	SQ	Moderately	2	0	IB	+	249	AGG → ATG	180	140	71.1	Alive
54	M	68	SQ	Moderately	2	0	IB	+	251	ATC → ACC	60	30	43.3	Alive
55	M	58	SQ	Moderately	1	0	IA	+	255	ATC → TTC	110	100	72.7	Alive
56	F	69	AD	Moderately	2	0	IB	−	265	CTG → TTG	0	200	60.3	Alive
57	F	70	LA	Poorly	2	1	IIB	+	266	GGA → GAA	0	20	30.6	Dead
58	M	74	SQ	Moderately	1	0	IA	+	270	TTT → TGT	0	180	68.0	Alive
59	M	50	SQ	Moderately	4	2	IIIB	−	270	TTT → TGT	0	150	11.3	Dead
60	M	71	SQ	Moderately	4	0	IIIB	+	273	CGT → CAT	50	180	11.7	Dead
61	M	78	SQ	Moderately	2	0	IB	+	273	CGT → CAT	70	150	12.1	Dead
62	M	48	SQ	Moderately	2	0	IB	−	273	CGT → TGT	60	80	77.5	Alive
63	M	55	AD	Moderately	2	1	IIB	+	273	CGT → TGT	0	180	22.7	Dead
64	F	61	AD	Poorly	2	2	IIIA	+	273	CGT → CTT	0	160	22.0	Dead
65	M	49	AD	Poorly	3	1	IIIA	+	273	CGT → CTT	0	300	8.1	Dead
66	M	69	AD	Moderately	1	2	IIIA	+	273	CGT → CGC	0	200	40.2	Alive
67	F	59	AD	Moderately	3	2	IIIA	−	275	TGT → TCT	0	300	38.8	Alive
68	M	71	LA	Poorly	1	2	IIIA	+	280	AGA → GGA	300	40	15.6	Dead
69	M	81	SQ	Moderately	2	0	IB	+	280	AGA → ACA	50	100	20.2	Dead
70	M	83	SQ	Well	4	0	IIIB	+	281	GAC → GAA	0	120	5.3	Dead
71	M	68	SQ	Poorly	2	0	IB	+	281	GAC → GAA	0	200	13.2	Dead
72	M	69	AD	Moderately	2	0	IB	+	283	CGC → CCC	0	100	11.2	Dead
73	M	68	SQ	Moderately	2	0	IB	+	283	CGC → CCC	50	60	66.8	Alive
74	M	54	AD	Poorly	1	2	IIIA	−	283	CGC → TGC	60	90	9.0	Dead
75	F	71	AD	Moderately	1	2	IIIA	−	285	GAG → AAG	0	200	43.1	Alive

Cases 42, 56, and 66 are non-missense mutations. T, tumor status; N, nodal status; M, male; F, female; LA, large-cell carcinoma; AD, adenocarcinoma; SQ, squamous cell carcinoma.