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. 2000 Jan;156(1):15–20. doi: 10.1016/s0002-9440(10)64700-1

Figure 2.

Figure 2.

A: Intraneuronal Aβ42 immunoreactivity (QCB) in layer II (islands of Calleja) of the entorhinal cortex (arrow) in a 90-year-old CDR1 patient, compared with the absence of staining (arrow) in an 83-year-old CDR2 patient; Aβ42 immunoreactive plaques can be seen above. In the CDR 2 patient, note the emergence of Aβ40 SPs. Bar = 100 μm. B: Abundant Aβ42 immunoreactivity (RU) compared with only occasional AT8 staining for hyperphosphorylated tau in the CA1 region of a 94-year-old patient (CDR 2). Bar = 60 μm. C: Adjacent sections of CA4 (below) and dentate gyrus (above) immunostained with antibodies to Aβ40, Aβ42 (QCB), and apoE in an 83-year-old cognitively impaired patient (CDR 2). Noticeable intraneuronal apoE staining is evident (inset, enlarged ×5). Bar = 100 μm.