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. 2000 Jan;156(1):15–20. doi: 10.1016/s0002-9440(10)64700-1

Figure 3.

Figure 3.

Metabolic labeling and immunoprecipitation of intraneuronal Aβ40 and Aβ42. A: Primary mouse neuronal cultures. Top: IP of conditioned medium indicates significantly lower secretion of Aβ42 compared with Aβ40. Bottom: Comparable amounts of Aβ40 and Aβ42 species in neuronal cell lysate. B: Aβ40 and Aβ42 species in sucrose density gradients from neuroblastoma cells harboring the Δ10eFAD PS1 mutation. Aβ1–40, Aβx-40, and Aβ1–42 species predominate in the Golgi-enriched fraction, whereas Aβx-42 predominates in the ER-enriched fraction.